Presentaciones

AIREAL 4 Montelukast 4mg. Envases conteniendo 30 y 60 comprimidos masticables.

AIREAL 5 Montelukast 5mg. Envases conteniendo 30 y 60 comprimidos masticables.

AIREAL 10 Montelukast 10mg. Envases conteniendo 30 y 60 comprimidos recubiertos ranurados.

• Tratamiento con nivel de evidencia A para rinitis alérgica estacional o perenne en niños o adultos.
  4,7,9
  
  
• Perfil de seguridad clínico y de laboratorio similar a placebo con el uso prolongado.
  1,2,3,4,5,6,7,8,9,10,11

• La incorporación de montelukast al tratamiento del asma con corticoides inhalados reduce las exacerbaciones, mejora la función pulmonar y el control del asma en adultos y niños.
  1,2,3,4,5,6,7,8
  
  
• Profilaxis y tratamiento crónico del asma o su asociación con el ejercicio o ácido acetilsalicílico y de la rinitis alérgica estacional o perenne en niños.
  1,2,3,4,5,6,7,8,9,10,11

Bibliografía

1- Hon KLE, Leung TF, Leung AKC. Clinical effectiveness and safety of montelukast in asthma. What are the conclusions from clinical trials and meta-analyses. Drug Design, Development and Therapy 2014;8:839-850.

2- Joos S, Miksch A et al. Montelukast as add-on therapy to inhaled corticosteroids in the treatment of mild to moderate asthma: a systematic review. Thorax 2008;63:453-462.

3- Paggiaro P, Bacci E. Montelukast in asthma: a review of its efficacy and place in therapy. Therapeutic Advances in Chronic Disease 2011;2(1):47-58.

4- Pacheco Y, Freymond N, Devouassoux G. Impact of montelukast on asthma associated with rhinitis and other triggers and co-morbidities. Journal of Asthma 2014;51(1):1-17.

5- Scichilone N, Battaglia S et al. Safety and efficacy of montelukast as adjunctive therapy for treatment of asthma in elderly patients. Clinical Interventions in Aging 2013;8:1329-1337.

6- Bérubé D, Djandji M et al. Effectiveness of montelukast administered as monotherapy or in combination with inhaled corticosteroid in pediatric patients with uncontrolled asthma: a prospective cohort study. Allergy, Asthma & Clinical Immunology 2014;10:21.

7- Buck ML. Montelukast: A Review of Recent Studies in Pediatric Asthma and Allergic Rhinitis. Pharm. 2015;21(4).

8- Chauhan BF et al. Addition of anti-leukotriene agents to inhaled corticosteroids for adults and adolescents with persistent asthma. Cochrane Database Syst Rev. 2017 Mar16;3.

9- Normas ARIA: Allergic Rhinitis and its Impact on Asthma. 2007.

10- Lagos JA, Marshall GD. Montelukast in the management of allergic rhinitis. Ther Clin Risk Manag 2007;3(2):327-332.

11- Baek HS, Cho J et al. Ratio of Leukotriene E4 to Exhaled Nitric Oxide and the Therapeutic Response in Children With Exercise-Induced Bronchoconstriction. Allergy Asthma Immonol Res 2013;5(1):26-33.

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